Non-hypertrophic chondrocytes

Non-hypertrophic chondrocytes are a type of chondrocyte, or cartilage-producing cell, that does not ultimately produce bone. Chondrocytes derived from adult stem cells enlarge (become hypertrophic) and change the cartilage they produce to bone tissue, a normal process called endochondral ossification. BioTime’s human embryonic progenitors produce chondrocytes that do not exhibit markers of hypertrophy (are non-hypertropic). This is a potential therapeutic advantage when the goal is to produce only cartilage for treating degenerative diseases.


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