PureStem® progenitor technology

The name of a proprietary technology that allows the large-scale and reproducible isolation of a diverse library of clonally purified human Embryonic Progenitor (hEP) cell types. Characteristics of hEP cells derived using ACTCellerate technology include extended propagation in vitro relative to adult stem cells, differentiation into cell types not obtained using fetal or adult-derived stem cells and the absence of diverse unidentified cell types, including undifferentiated pluripotent stem cells.

Examples of peer-review scientific publications on cells made using the PureStem technology include:

  1. A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme.
  2. Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates.
  3. Identification of human embryonic progenitor cell targeting peptides using phage display.
  4. Defining cell-matrix combination products in the era of pluripotency.
  5. Human embryonic stem cell-derived neural crest cells capable of expressing markers of osteochondral or meningeal-choroid plexus differentiation.
  6. Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line.
  7. Selection of Phage Display Peptides Targeting Human Pluripotent Stem Cell-Derived Progenitor Cell Lines.