HetaFreeze is one of a family of BioTime's freeze-protective solutions which may ultimately allow the extension of time during which organs and tissues can be stored for future transplant or surgical grafting. BioTime's proprietary freeze-protective compounds have already been used to preserve skin when used as a whole animal perfusate. Silver dollar size full thickness shaved skin samples have been removed after saturation with HetaFreeze solution, frozen at liquid nitrogen temperatures and stored for periods ranging from days to weeks. The grafts were then warmed and sewn onto the backs of host animals. Many of these grafts survived.
In other laboratory experiments, BioTime scientists have shown that animals can be revived to consciousness after partial freezing with their blood replaced by HetaFreeze. While this technology has not developed to an extent that allows long term survival of the laboratory subjects, it may have applications in the freezing and long term storage of tissues such as blood vessels and skin.
Whole Body Cooling and Organ Preservation
The donor is placed on bypass and cooled to near-freezing with BioTime's organ preservation solution.
The heart, lung, kidneys, liver, and pancreas are removed, refrigerated and shipped to recipients.
Infusion of a second freeze-protecting solution allows the harvesting of skin, bone, joints, and other tissues which can survive storage at cryogenic temperatures.
BioTime, Inc. 1301 Harbor Bay Pkwy Alameda, CA 94502 tel: 510.521.3390 fax: 510.521.3389
The donor is placed on bypass and cooled to near-freezing with BioTime's organ preservation solution.
The heart, lung, kidneys, liver, and pancreas are removed, refrigerated and shipped to recipients.
Infusion of a second freeze-protecting solution allows the harvesting of skin, bone, joints, and other tissues which can survive storage at cryogenic temperatures.
